WHO confirms quarantine lifting: the last remaining monitored contacts of the MV Hondius Andes hantavirus outbreak have been released or are in the process of release. The 42-day monitoring window — chosen to cover the maximum known ANDV incubation period — has now closed for virtually all exposed individuals. No new cases have been confirmed since Spain Case 3 (25–26 May).
RIVM (Netherlands) confirms: almost all MV Hondius passengers and crew have now completed their 42-day quarantine. All re-tests before release returned negative results. One person remains in extended quarantine due to close contact with a hospitalized patient. One Dutch national who tested positive in late May remains hospitalised in stable condition. Another Dutch individual with a weak-positive signal subsequently tested negative and is not considered a case.
ECDC publishes its final active surveillance update: 12 confirmed + 1 probable = 13 total cases, 3 deaths, CFR 23% — one previous probable case reclassified to confirmed. Almost all quarantine periods have now been completed. One person remains in extended quarantine due to close contact with a hospitalized case. Risk to the EU/EEA general population remains very low.
MV Hondius departs Longyearbyen, Svalbard on its first post-outbreak Arctic expedition (North Spitsbergen, 13–20 June 2026). The ship was fully disinfected and certified rodent-free by EWS Group; all crew completed or are completing 42-day quarantine. Return to service marks the end of the operational response to the outbreak.
WHO announces NAVIS (Natural history study on Andes virus): a 21-country coordinated research initiative launched by investigators from Australia, Belgium, Canada, DRC, Denmark, France, Germany, Greece, Ireland, Italy, Japan, Netherlands, New Zealand, Singapore, South Africa, Spain, Switzerland, Türkiye, UK, and USA. Coordinated by Hospital Germans Trias i Pujol (Spain), ANRS-MIE, and CORC using the ISARIC framework. Aims to improve understanding of ANDV transmission dynamics, incubation periods, immune responses, viral kinetics and determinants of severe disease through longitudinal follow-up of exposed individuals.
Saint Helena government declares the hantavirus incident concluded: no active, suspected, or confirmed cases on the island. The South Atlantic component of the outbreak is fully resolved.
米国の42日間監視期間終了：国家検疫ユニット（UNMC、ネブラスカ州）のMVホンディウスの米国人乗客18名全員が監視期間を完了した。ハンタウイルス感染症は検出されなかった。CDCは米国人乗客に対するこれ以上の公衆衛生フォローアップは不要と確認した。
MVホンディウスのロッテルダムでの除染が完了（5月29〜30日）：EWSグループの13名の生物安全専門家が全8デッキを清掃し、齧歯類不在を確認。オランダ当局が運航可能と宣言。6月6日にロングイェールビーン向けてロッテルダムを出発。最初の北極圏遠征：6月13日、スバールバル諸島のロングイェールビーン出発。
MV Hondius decontamination completed in Rotterdam (29–30 May): EWS Group's 13 biosecurity experts cleared all 8 decks and confirmed rodent-free status. Ship cleared for operations by Dutch authorities. MV Hondius departs Rotterdam for Longyearbyen, Svalbard on 6 June; first post-outbreak Arctic expedition remains scheduled to depart Longyearbyen on 13 June 2026.
ECDC updates to 13 total cases (11 confirmed + 2 probable), 3 deaths, CFR 23% — reflecting Spain's new confirmed case. Case definition revised to align with WHO: confirmed now requires laboratory confirmation of ANDV by PCR and/or serology. WHO DG Tedros: 'Spain reported a new case among the passengers who are in quarantine, which brings the total number of cases to 13. The situation remains stable.' HantaCount headline updates to 18 cases; Spain total rises to 3.
Spain confirms third hantavirus case: a second Spanish national among the 14 MV Hondius passengers quarantined at Gómez Ulla Central Defence Hospital (Madrid) tests PCR-positive during routine periodic diagnostic screening. Patient transferred to High-Level Isolation Unit. Detected within the activated surveillance and control system; Spain's Health Ministry states the case does not change the public health risk assessment.
ECDCが2026年5月21日の疫学サーベイランス更新を発行：5月16日以降、新規症例・死亡なし。ECDC公式集計：9件の検査確認＋2件の可能性例＝計11症例、3名死亡、致命率27%。EU/EEA一般市民へのリスクは依然として非常に低い。最新のWHO DON：DON-601（5月13日）。
スペイン情報：マドリードのゴメス・ウジャ国防中央病院で隔離中の70歳のスペイン人MVホンディウス乗客は「順調に回復中」。同じ病棟の高リスク接触者13名（全員陰性）は、PPEを着用しながら共有スペースを移動し、段階的な安全な面会を受けることが許可された。院内の接触者間での交差感染は確認されていない。
CDCがネブラスカ州の国家検疫ユニット（UNMC）を離れようとした米国人乗客2名に対し、公衆衛生サービス法に基づく正式な隔離命令を発令。18名全員が5月31日（監視21日目）まで施設に留まるよう要請された。フランス・スペイン・カナダの3件の新たな国際症例が確認されたことを受け、当初「自発的」とされていた滞在が強制的なものとなった。
MVホンディウスが5月18日19:30 CETにロッテルダムに着岸。フィリピン人17名とウクライナ人3名の計20名の非オランダ人乗組員が港のコンテナ改造キャビンで6週間の隔離に入る。オランダ人乗組員は監視下で帰宅。5月2日に死亡した乗客の遺体が火葬のため船から運び出される。EWSグループが3〜4日の消毒を開始。船は6月13日にスバールバル諸島のロングイェールビーンから出港予定。
カナダが最初の症例を確認：ブリティッシュコロンビアに帰国したMVホンディウスの乗客がアンデスハンタウイルスの推定陽性を示した — ECDCが確認症例として分類。患者は軽症で自宅隔離中。HantaCountの見出しを16症例・15カ国・致命率19%に更新。
Canada confirms first case: a returned MV Hondius passenger in British Columbia tests presumptively positive for Andes hantavirus — ECDC classifies as confirmed. Patient has mild symptoms and is quarantined at home. HantaCount headline updates to 16 cases, 15 countries, CFR 19%.
WHO and UKHSA jointly convene Emergency Scientific Consultation on Andes Virus Medical Countermeasures (MCM) in Geneva — experts, researchers and public health authorities from affected countries prioritise the vaccine and antiviral R&D pipeline for Andes hantavirus. First dedicated ANDV MCM workshop at WHO level, triggered by the MV Hondius outbreak.
France Health Minister Stéphanie Rist: all 26 close contacts of the two confirmed French cases PCR-tested negative for Andes hantavirus. The 27 French nationals under highest surveillance (2 confirmed cases + 25 contacts/household) continue weekly testing under France's 45-day quarantine protocol. Case 1 remains critically ill on ECMO at Hôpital Bichat-Claude-Bernard; no further deterioration reported.
Italy: all 4 persons quarantined following exposure on the KLM Johannesburg–Amsterdam flight (25 April) — including a 25-year-old Calabrian man who developed hantavirus-compatible symptoms — test negative for Andes hantavirus at Spallanzani Institute (Rome) and a Milan laboratory. Italy not added to HantaCount country list.
US inconclusive case (Nebraska Biocontainment Unit) retested NEGATIVE: CDC and UNMC confirm the result resolves to negative. Patient (Dr. Stephen Kornfeld, 69, Bend OR — retired oncologist who voluntarily cared for ill passengers onboard) released from biocontainment unit to Davis Global Center standard quarantine facility. HantaCount US total: 0 confirmed cases. Headline total drops from 16 to 15.
ECDC publishes new technical guidance: 'Advice on laboratory testing of Andes virus (ANDV) for high-risk contacts under the MV Hondius outbreak'. Aligns serology + PCR testing protocols across receiving countries; addresses discordant-result handling (relevant to the inconclusive US case).
MV Hondius repatriation flights #2 and #3 — all passengers tested negative for hantavirus. Combined with the 1 inconclusive on flight #1, this leaves the only ongoing confirmed/probable cases as those previously reported. No new repatriation-discovered cases.
Radboud UMC update: all 12 quarantined Nijmegen hospital staff blood tests negative — no ANDV transmission confirmed. Dutch healthcare union CNV publicly condemns the protocol breach; Radboud admits the latest international ANDV-specific guideline was not yet available to staff at the time of exposure. Staff to remain in 6-week observational quarantine as precaution.
Spain Case 2 (Madrid, Gómez Ulla hospital) develops low-grade fever and mild respiratory symptoms — previously asymptomatic. Stable but progressing under close monitoring. ANDV onset window matches WHO timeline (1–8 weeks post-exposure).
ECDC urges quarantine for high-risk contacts on the LIFT St. Helena–Johannesburg (24 April) and KLM Johannesburg–Amsterdam (25 April) flights — specifically passengers in the same row or two rows in front/behind a confirmed case. Italy reports a 25-year-old man who travelled on the KLM flight has developed hantavirus-compatible symptoms; 4 Italian passengers placed under quarantine. First reported off-ship exposure under active investigation. Italy is not yet added to the HantaCount country list pending Italian health authority case classification.
France Case 1 critically ill: French repatriated passenger at Hôpital Bichat-Claude-Bernard (Paris) is placed on ECMO (extracorporeal membrane oxygenation) for life-threatening cardiopulmonary failure consistent with hantavirus pulmonary syndrome (HCPS). Patient is the in-flight symptomatic case from 11 May; condition has rapidly deteriorated.
Illinois IDPH investigates potential hantavirus case in Winnebago County — explicitly NOT linked to MV Hondius. Strain identified as Sin Nombre virus (SNV), a North American rodent-borne hantavirus unrelated to Andes virus (ANDV). SNV is not person-to-person transmissible; patient is recovering with mild symptoms and did not require hospitalisation. This case is not included in HantaCount headline total.
ECDC updates official count: one previously confirmed case reclassified as 'inconclusive' after further laboratory review. New ECDC tally aligns with WHO DON-601: 8 lab-confirmed + 2 probable + 1 inconclusive = 11, 3 deaths. HantaCount headline remains 16 (no change in national health agency confirmations). No new countries report cases.
WHO publishes DON-601: third Disease Outbreak News on the cluster. Confirms 11 cases (8 lab-confirmed ANDV + 2 probable + 1 inconclusive), 3 deaths (2 confirmed + 1 probable), CFR 27%. Inconclusive case is a US passenger with discordant results between two labs (one positive, one negative) — retesting under way. WHO risk assessment: low globally, moderate for those on board. Preliminary sequencing: cases differ by ≤1 SNP, indicating a single (or very small number of) zoonotic spillover event(s). Working hypothesis remains that index case was infected on land in Argentina/Chile (likely during bird-watching activity) before boarding the ship.
US update: 16 Americans at Nebraska Biocontainment Unit (1 confirmed, 15 monitoring); 2 at Emory University Hospital Atlanta — 1 symptomatic, PCR negative (hantavirus ruled out); 1 monitoring. Tristan da Cunha community PCR screening results from GeneXpert rig still pending.
ECDC updates official count to 11 (9 lab-confirmed + 2 probable), 3 deaths. MV Hondius departs Tenerife for Rotterdam for crew offload and ship-wide hantavirus decontamination (4–6 weeks). WHO Director-General: 'There is no sign that we're seeing the start of a larger outbreak.'
WHO Director-General Tedros Adhanom Ghebreyesus, briefing reporters in Tenerife, said: "This is not another COVID. The risk to the public is low." Tedros reiterated that human-to-human Andes virus transmission is limited to close-contact settings and that the multi-country evacuation should not change the overall WHO public-risk assessment, which remains very low.
CDC activates Level 3 emergency response for the MV Hondius outbreak — the agency's mid-tier activation that mobilises an Emergency Operations Center team and deploys epidemiologists and medical staff to the affected region. The CDC team is conducting per-passenger exposure risk assessments for the 18 repatriated US nationals and is coordinating with HHS on the Nebraska Biocontainment Unit transfer.
France confirms second case: a French woman evacuated from MV Hondius tests PCR-positive — the second of 5 repatriated French nationals to test positive. France total: 2 cases. HantaCount headline updates to 16 cases, CFR 19%.
Spain confirms second case: a Spanish male passenger in Madrid hospital tested PCR-positive on arrival screening; asymptomatic and in good health. This is distinct from the May 8 Alicante case (South African woman). Spain total: 2 cases.
Radboud UMC (Nijmegen, Netherlands): 12 hospital staff placed in 6-week preventive quarantine after protocol breaches in handling an MV Hondius patient. Blood samples were processed under standard rather than ANDV-strict protocol; urine disposal did not follow latest international guidelines. Hospital states the probability of actual infection is very small.
First US case confirmed: HHS announced one of the 18 repatriated American passengers tested PCR-positive for Andes hantavirus on the trans-Atlantic flight (asymptomatic at testing). Patient transported in a biocontainment unit to the Nebraska Biocontainment Unit at University of Nebraska Medical Center for follow-up. A second American with mild symptoms is being routed to a separate ASPR RESPTC. HantaCount headline updates to 14 cases (13 + 1 US PCR-positive), CFR 21%.
Methodology lock-in: HantaCount headline aligned to the sum of national health agency reports (NL 2 + ZA 1 + GB 3 + CH 1 + ES 1 + DE 1 + FR 1 + TR 1 + CV 1 + SH 1 = 13 cases, 3 deaths, CFR 23%). Each country count now carries an explicit source. WHO DON-600 baseline (8 cases, 6 lab-confirmed + 2 probable, CFR 38%) shown separately for direct comparison.
Updated disembarkation count: 94 of the 147 onboard passengers disembarked on the first day (10 May), representing 19 different nationalities. Beyond the 13 countries with cases, additional passenger nationalities include Australia, Belgium, Greece, Guatemala, India, Japan, Montenegro, New Zealand, Poland, Portugal, Russia and Ukraine — these countries are conducting precautionary contact monitoring even though no cases have been confirmed among their nationals.
WHO coordinates shipment of 2,500 Andes virus diagnostic kits from Instituto Malbrán (Argentina) to reference laboratories in Spain, France, Netherlands, United Kingdom and South Africa. Tristan da Cunha team installs Cepheid GeneXpert PCR rig at Camogli Hospital — first community screening results expected within 48 hours.
Tenerife disembarkation operation completes. UK Health Security Agency confirms a third British national positive for Andes virus on the repatriation flight. One French passenger develops symptoms in-flight to Paris and is isolated on arrival at Bichat. WHO updated Tristan da Cunha case timeline: probable case is an adult male resident who disembarked at Saint Helena on 14 April, symptom onset 28 April (diarrhoea, then fever); currently stable in isolation. One previously suspected case has been reclassified as non-case after PCR and serology negative.
WHO confirms 46 passengers disembarked at Tenerife in the first wave; first Spanish charter (14 passengers) reached Madrid. France evacuates 5 nationals to Paris under 72-hour hospital observation + 45-day home quarantine protocol. UK military paratroopers airdrop medical clinicians and equipment to Tristan da Cunha. After full disembarkation MV Hondius will continue to Rotterdam for crew offload and ship-wide disinfection.
Spanish health authorities confirm disembarkation order: Spanish nationals first, flown to Madrid Gomez-Ulla military hospital for quarantine; followed by Netherlands, Canada, Türkiye, France, United Kingdom, Ireland and United States. Spain's health minister states remaining passengers are asymptomatic.
Passenger disembarkation begins at Tenerife under strict medical supervision. UK Health Security Agency confirms second British case.
スペイン保健当局が下船順序を確認：スペイン人を最優先とし、検疫のためマドリードのゴメスウジャ陸軍病院へ空輸。続いてオランダ、カナダ、トルコ、フランス、英国、アイルランド、米国。スペイン保健相は残乗客が無症状と発表。
テネリフェで医療監視のもと乗客の下船が開始。英国健康安全保障庁が2番目の英国症例を確認。
トリスタンダクーニャ政府が4月24日に下船した住民のハンタウイルス疑い症例を報告。ホンディウスを航空機で離れた乗組員が陰性と判明。
WHOがDON-600を発行：8症例（確認6件・疑い2件）、3名死亡、致命率38%。船がテネリフェに入港。5月10日に乗客の下船を計画。米国人17名がオファット空軍基地に帰国予定。強制隔離なし。
MVホンディウスがテネリフェ（グラナディジャ・デ・アボナ港）に到着。WHO事務局長が船内147名の下船調整のためカナリア諸島へ。フランスとシンガポールが接触者追跡ネットワークに追加。7つの米国州が乗客を監視中。
CDCが帰国便を発表。スペインがアリカンテで症例を確認。米国が5州で監視を実施。
スイスが最初の欧州症例を確認。40名の乗客が避難。
アルゼンチンがクルーズ前の曝露源についての調査を開始。
WHOが疾病発生報告（DON-599）を発行 — アンデスウイルス確認。
船内で2名死亡。PCR検体がリスボンに送られる。
最初の乗客がインフルエンザ様症状を報告。
数十名の乗客がセントヘレナで下船。後に接触者追跡のため特定される。
MVホンディウスが240名以上の乗客を乗せてアルゼンチンを出港。